Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F
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چکیده
منابع مشابه
Synthesis of a des-B-Ring Bryostatin Analogue Leads to an Unexpected Ring Expansion of the Bryolactone Core
A convergent synthesis of a des-B-ring bryostatin analogue is described. This analogue was found to undergo an unexpected ring expansion of the bryolactone core to generate the corresponding 21-membered macrocycle. The parent analogue and the ring-expanded product both displayed nanomolar binding affinity for PKC. Despite containing A-ring substitution identical to that of bryostatin 1 and disp...
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The bryostatins are a family of marine natural products that display a wide range of biological activities, most notably their anticancer activity in vivo.1 This effect is attributed to their ability to modulate the functions of protein kinase C isozymes within cells. One of the members of this family, bryostatin 1, is currently in several phase I and phase II clinical trials for the treatment ...
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ژورنال
عنوان ژورنال: The Journal of Organic Chemistry
سال: 2020
ISSN: 0022-3263,1520-6904
DOI: 10.1021/acs.joc.0c01659